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13 July 2011

Crystal clear results with Tecan’s CrysScreen™

The Protein Expression Purification Crystallization Core (PEPCC) at Case Western Reserve University, Ohio, is a state-of-the-art facility for high throughput protein crystallization, taking advantage of the automation capabilities of Tecan’s CrysScreen™ software and Freedom EVO® liquid handling platform to optimize crystallization parameters. Dr Harry Gill, Assistant Professor and Director of the PEPCC, explained: “Automation of high throughput crystallization trials is crucial, ensuring accurate pipetting while minimizing the amount of protein required for each experiment. We evaluated a variety of liquid handling systems when we set up the PEPCC, and the availability of the specialized CrysScreen software, together with the flexibility of the Freedom EVO platform, made the Tecan system an obvious choice for this role.”

“CrysScreen is fully integrated into the liquid handling platform’s Freedom EVOware® control software, providing fully automated design and preparation of optimization experiments in which crystallization parameters – such as pH, salt and precipitant concentration – are adjusted to improve crystal formation and quality. Thanks to CrysScreen, we are able to set up crystallization trials very quickly, achieving in minutes what would have taken almost a week to perform manually.”

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