Traductor

22 October 2010

New JUPITER Analysis Demonstrates CRESTORTM (rosuvastatin) Significantly Reduces Major Cardiovascular Events in High Risk

A post-hoc-analysis from JUPITER published in the European Heart Journal shows CRESTOR(TM) (rosuvastatin) 20 mg significantly reduced major cardiovascular (CV) events, defined as the combined end-point of CV death, stroke and myocardial infarction, compared to placebo, by 50% (p=0.028; CI 0.27-0.93) in high risk patients with a 10-year Framingham risk score >20% and by 43% in patients with an extrapolated SCORE risk greater than or equal to 5% (p=0.0003; CI 0.32-0.68). The risk reductions observed in this patient population were consistent with those seen in the primary JUPITER analysis.
This analysis is based on subgroup data from the landmark JUPITER study which studied men and women with low to normal LDL-C cholesterol levels but at increased cardiovascular risk as identified by age and elevated hsCRP.
"This newly published analysis of the JUPITER study reinforces the importance of rosuvastatin as an appropriate treatment option to reduce the risk of major cardiovascular events in high-risk patients as defined by the Framingham and SCORE risk factor assessment tools," said Michael Cressman, Executive Director of Clinical Research for CRESTOR. "Clinical studies have previously shown that rosuvastatin was the most effective statin at lowering LDL-C, had a significant effect on raising HDL-C and taken together with this analysis of JUPITER data, provides physicians with important information to help effectively reduce CV risk."
This analysis, now published in the European Heart Journal, was the basis for the approval of CRESTOR in April in 19 EU countries, for the prevention of major CV events in patients who are at high risk* of having a first cardiovascular event.
In JUPITER, rosuvastatin 20 mg was well tolerated in nearly 9,000 patients. There was no difference between treatment groups for major adverse events. There was a small increase in physician reported diabetes which is in line with data from other large placebo controlled statin trials. This finding has been reflected in the updated Summary of Product Characteristics (SmPC).

*high risk patients defined as having a SCORE greater than or equal to 5% or Framingham > 20%.

No comments:

Post a Comment

CONTACTO · Aviso Legal · Política de Privacidad · Política de Cookies

Copyright © Noticia de Salud